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Symptoms and treatment for overdose and antidotes: Claritrox 250 mg Tablet: Reports indicate that the ingestion of large amounts of clarithromycin can be expected to produce gastrointestinal symptoms. One patient who had a history of bipolar disorder ingested 8 g of clarithromycin and showed altered mental status, paranoid behaviour, hypokalemia and hypoxemia. Allergic reactions accompanying overdosage should be treated by the prompt elimination of unabsorbed drug and supportive measures.
Metgyl 400 mg Tablet: Symptoms: One case report of a voluntary overdose of 4200 mg in a 16-year-old pregnant woman reported that the patient developed disorientation, which resolved without specific treatment. Larger doses than this reported overdose have been given to patients as a radiosensitizer without severe toxicity.
Treatment: Since there is no specific antidote, treatment for metronidazole overdose should be symptomatic and supportive.
Omilock 20 mg Capsule: None has been reported; Single oral doses of up to 160 mg and total oral doses of up to 300 mg/day have been given without adverse effects.
Symptoms/Clinical Effects of overdose: The following effects have been selected on the basis of their potential clinical significance: Blurred vision; confusion; diaphoresis (increased sweating); drowsiness; dryness of mouth; flushing; headache; nausea; tachycardia (fast or irregular heartbeat).
Treatment: Since there is no specific antidote for overdose with omeprazole, treatment should be symptomatic and supportive. Due to extensive protein binding, omeprazole is not readily dialyzable. Patients in whom intentional overdose is confirmed or suspected should be referred for psychiatric consultation.
